(400 mg/day) for 1 week. In a healthy volunteer study of itraconazole intravenous infusion, transient, asymptomatic decreases in left ventricular ejection fraction were observed using gated SPECT imaging; these resolved before the next infusion, 12 hours later.
For optimal absorption, SPORANOX Oral Solution should be taken without food (patients are advised to refrain from … The study is created by eHealthMe based on reports of 10 people who take Arava and Sporanox from the Food and Drug Administration (FDA), and is updated regularly.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
The table lists adverse events reported by at least 1% of patients.Adverse events infrequently reported in all studies included constipation, Patients in these trials were on a continuous dosing regimen of 200 mg once daily for 12 consecutive weeks.The following adverse events led to temporary or permanent discontinuation of therapy.The following adverse events occurred with an incidence of greater than or equal to 1% (N=112): headache: 10%; rhinitis: 9%; upper respiratory tract infection: 8%; sinusitis, injury: 7%; diarrhea, dyspepsia, flatulence, abdominal pain, dizziness, rash: 4%; cystitis, urinary tract infection, liver function abnormality, myalgia, nausea: 3%; appetite increased, constipation, gastritis, gastroenteritis, pharyngitis, asthenia, fever, pain, tremor, herpes zoster, abnormal dreaming: 2%.Patients in these trials were on a pulse regimen consisting of two 1-week treatment periods of 200 mg twice daily, separated by a 3-week period without drug.The following adverse events led to temporary or permanent discontinuation of therapy.The following adverse events occurred with an incidence of greater than or equal to 1% (N=37): headache: 8%; pruritus, nausea, rhinitis: 5%; rash, bursitis, anxiety, depression, constipation, abdominal pain, dyspepsia, ulcerative stomatitis, gingivitis, hypertriglyceridemia, sinusitis, fatigue, malaise, pain, injury: 3%.In addition, the following adverse drug reaction was reported in patients who participated in SPORANOXThe following is a list of additional adverse drug reactions associated with itraconazole that have been reported in clinical trials of SPORANOXAdverse drug reactions that have been first identified during post-marketing experience with SPORANOXThere is limited information on the use of SPORANOXItraconazole and its major metabolite, hydroxy-itraconazole, are potent CYP3A4 inhibitors. Combining fluconazole with amiodarone , pimozide , bepridil or other drugs that affect heart rhythm may increase the risk of abnormal heart rhythms.
Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.Many drugs can interact with itraconazole, and some drugs should not be used at the same time.
Ask your doctor about any risk.Itraconazole can pass into breast milk and may affect the nursing baby.
These medications are not usually taken together. Results of these two studies demonstrated substantial evidence of the effectiveness of itraconazole for the treatment of Analyses were conducted on data from two open-label, non-concurrently controlled studies (N=34 combined) in patients with normal or abnormal immune status (not including HIV-infected patients). Does Sporanox Solution Interact with other Medications? This includes prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sporanox only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. As a consequence of non-linear pharmacokinetics, itraconazole accumulates in plasma during multiple dosing.
You may report side effects to FDA at 1-800FDA-1088.Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
Before taking this medicine.
This is not a complete list of side effects and others may occur. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Anyone who takes gastric acid inhibitors should give their physician a list of all the other medicines that he or she is taking. Itraconazole has been shown to cross the placenta in a rat model. If signs or symptoms of congestive heart failure occur during administration of SPORANOX ® …
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