Table 4 provides combined data for the pool of studies that are provided separately by indication in Table 3.Associated With Discontinuation In Major Depressive Disorder, OCD, Bulimia, And Panic Disorder Placebo-Controlled Clinical Trials (excluding data from extensions of trials)Table 5 lists the adverse reactions associated with discontinuation of PROZAC treatment (incidence at least twice that for placebo and at least 1% for PROZAC in clinical trials collecting only a primary reaction associated with discontinuation) in Major Depressive Disorder, OCD, bulimia, and Panic Disorder clinical trials, plus non-US Panic Disorder clinical trials.Treatment-emergent adverse reactions were collected in 322 pediatric patients (180 fluoxetine-treated, 142 placebo-treated). Although some patients achieved freedom from binge-eating and purging as a result of treatment, for the majority, the benefit was a partial reduction in the frequency of binge-eating and purging.In a longer-term trial, 150 patients meeting DSM-IV criteria for Bulimia Nervosa, purging subtype, who had responded during a The effectiveness of PROZAC in the treatment of Panic Disorder was demonstrated in 2 double-blind, randomized, placebo-controlled, multicenter studies of adult outpatients who had a primary diagnosis of Panic Disorder (DSM-IV), with or without agoraphobia.Study 1 (N=180 randomized) was a 12-week flexible-dose study. PROZAC can increase the levels of pimozide and thioridazine through inhibition of CYP2D6. Fluoxetine might assist in keeping thunderstorm phobias in check by calming your dog.Any out-of-routine situation in your dog’s life can trigger canine depression. For example, a 30-pound dog might take 15 to 27 mg per day. Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide.

Symbyax is dosed between 3 mg/25 mg (olanzapine/fluoxetine) per day and 12 mg/50 mg (olanzapine/fluoxetine) per day. Fluoxetine combined with behavioral therapy has been shown to help with separation anxiety.With compulsive disorders, these behaviors are repetitive ones that occur It may also help for other canine compulsions such as:Shaking and avoidance are both characteristic signs of fear in dogs and often occur during thunderstorms. This can lead to anaphylaxis, which can be deadly. In Study 2, patients receiving PROZAC experienced mean reductions of approximately 4 to 9 units on the YBOCS total score, compared with a 1-unit reduction for placebo patients. It may harm them.This Medication Guide summarizes the most important information about PROZAC. Make dosage adjustments, if indicated, according to efficacy and tolerability. PROZAC produced a statistically significantly greater mean change from baseline to endpoint than did placebo as measured by the Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS).Subgroup analyses on outcome did not suggest any differential responsiveness on the basis of age or gender.The effectiveness of PROZAC for the treatment of bulimia was demonstrated in two 8-week and one 16-week, multicenter, parallel group studies of adult outpatients meeting DSM-III-R criteria for bulimia. Published epidemiological studies of pregnant women exposed to fluoxetine have not established an increased risk of major birth defects, miscarriage, and other adverse developmental outcomes. Consequently, healthcare providers should carefully evaluate patients for history of drug abuse and follow such patients closely, observing them for signs of misuse or abuse of PROZAC (e.g., development of tolerance, incrementation of dose, drug-seeking behavior).When using PROZAC and olanzapine in combination, also refer to the Warnings and Precautions section of the package insert for Symbyax.Patients with Major Depressive Disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs.

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