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The single- and multiple-dose pharmacokinetics of citalopram are linear and dose-proportional in a dose range of 10-60 mg/day.
No adjustment of dosage for such patients is recommended.
The maximum dosage for citalopram is 40 milligrams per day. Do not drink alcohol while using Celexa.Common possible side effects in people who take Celexa includeOther side effects in children and adolescents include:Tell your healthcare provider if you have any side effect that bothers you or that does not go away. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, Celexa should be stopped promptly, and linezolid or intravenous methylene blue can be administered. Your doctor may be able to change your dose of Celexa to ease symptoms or recommend a different medication.Sleep problems may occur while taking Celexa. Symptoms can include:If you need to stop taking Celexa, your doctor will help you decrease your dose slowly to help avoid these symptoms. While these events are generally self-limiting, there have been reports of serious discontinuation symptoms.Patients should be monitored for these symptoms when discontinuing treatment with Celexa. At steady state, the concentrations of citalopram's metabolites, DCT and DDCT, in plasma are approximately one-half and one-tenth, respectively, that of the parent drug. Several recent epidemiologic studies suggest a positive statistical association between SSRI use (including Celexa) in pregnancy and PPHN. Celexa options creep 10, but it worked and benefits to habitual, which is why we thought of a history of you are now welcome to avoid out. They can review your medications and recommend the right treatment for you.If you need to take a triptan while you’re using Celexa, your doctor will monitor you closely for symptoms of serotonin syndrome.The medication carbamazepine (Tegretol) may speed up the breakdown of Celexa in the body. In study 2, a 4-week, placebo-controlled trial in depressed patients, of whom 85% met criteria for melancholia, the initial dose was 20 mg/day, followed by titration to the maximum tolerated dose or a maximum dose of 80 mg/day.
A medication timer may be useful, too.Celexa is meant to be used as a long-term treatment. Most elderly patients treated with Celexa in clinical trials received daily doses between 20 and 40 mg (see SSRIs and SNRIs, including Celexa, have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse event (see In two pharmacokinetic studies, citalopram AUC was increased by 23% and 30%, respectively, in subjects ≥ 60 years of age as compared to younger subjects, and its half-life was increased by 30% and 50%, respectively (see 20 mg/day is the maximum recommended dose for patients who are greater than 60 years of age (see The premarketing development program for Celexa included citalopram exposures in patients and/or normal subjects from 3 different groups of studies: 429 normal subjects in clinical pharmacology/pharmacokinetic studies; 4422 exposures from patients in controlled and uncontrolled clinical trials, corresponding to approximately 1370 patient-exposure years. This means citalopram is the ingredient that makes Celexa work.Citalopram also comes as an oral liquid solution and as a tablet that dissolves on your tongue.Celexa can cause mild or serious side effects. Tell them about all prescription, over-the-counter, and other drugs you take. These people were compared with people who took a placebo. Consequently, it is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse events without first grouping similar types of events into a smaller number of standardized event categories. The people in the Celexa group were less likely to have their depression come back again.In addition to the use listed above, Celexa may be used off-label. If you’re taking Celexa, you can also use medications known as However, you should be cautious about driving or operating machinery until you know how these drugs affect you. Therapy with Celexa may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue (see The risk of administering methylene blue by non-intravenous routes (such as oral tablets or by local injection) or in intravenous doses much lower than 1 mg/kg with Celexa is unclear.
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