2009;150(9):604–12.Hedberg EC, Ayers S. The power of a paired t-test with a covariate. Am J Kidney Dis.

AIDS (London, England).

Soc Sci Res. Antiviral Res. All authors read and approved the final manuscript.This study was conducted in accordance with the Declaration of Helsinki and applicable local and national guidelines. Lancet Infect Dis. Although a highly significant trend between lower pre-switch eGFR and eGFR improvement post-switch to TAF was observed, further study will be needed in larger patient groups to better characterize the relationship between baseline eGFR change and the eGFR response in patients switched from TDF to TAF-containing regimens. 2017;4(5):e195–204.Orkin C, Molina JM, Negredo E, Arribas JR, Gathe J, Eron JJ, et al.
Lancet HIV. Lancet HIV. Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence. Although ongoing TDF exposure has previously been shown to reduce eGFR, the effect is modest [Our findings support the recommendation of the European society guidelines, that patients receiving TDF with an eGFR > 60 mL/min should be considered for switch if their eGFR has declined by 5 mL/year for three or more years and/or their eGFR has decreased > 25% from baseline [The main limitation of this study was the sample size. Switching from tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study.

Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study. This suggests that patients on TDF with poorer baseline renal function would benefit more from switching to TAF.

Search New Onset or Worsening Renal Impairment: Renal impairment, including cases of acute renal failure and Fanconi syndrome, has been reported with the use of tenofovir prodrugs. This procedure increases precision by adjusting for the mean-centered independent variable [A total of 79 HIV-positive patients were identified that had switched from a TDF- to TAF-containing antiretroviral regimen and were included in the analysis. Further study to explore this association is warranted.Modern combination antiretroviral therapy (cART) is highly efficacious in virological suppression of HIV-infection [TDF remains widely used and a recommended first-line antiretroviral by major international societies [There are limited other data on factors which may predict improvements in renal function with the switch of antiretroviral regimen. Renal function of participants in the Bangkok tenofovir study–Thailand, 2005–2012. Tenofovir alafenamide as part of a salvage regimen in a patient with multi-drug resistant HIV and tenofovir-DF-associated renal tubulopathy. The apparent total body clearance at steady state (CL/F) increased with age over the 3-month period with a corresponding decrease in AUC.

Tenofovir alafenamide versus tenofovir disoproxil fumarate: is there a true difference in efficacy and safety? 2014;59(5):716–24.Mocroft A, Lundgren JD, Ross M, Fux CA, Reiss P, Moranne O, et al.

2018;4(2):72–9.Panel on Atriretroviral Guidelines for Adults and Adolescents. By continuing to browse the site you are agreeing to our policy on the use of cookies. 2012;26(7):867–75.Hagins D, Orkin C, Daar ES, Mills A, Brinson C, DeJesus E, et al. Ethics approval for this project was obtained from the RPAH Zone Human Research Ethics Committee of the Sydney Local Health District (Protocol Number X18-0015). HIV Med. 2018;5(5):91–5.Scherzer R, Estrella M, Li Y, Choi AI, Deeks SG, Grunfeld C, et al. 2011;57(5):773–80.Mugwanya KK, Wyatt C, Celum C, Donnell D, Kiarie J, Ronald A, et al. 2018;19(10):724–33.Dr Valerie Gracey—for kindly lending her statistical expertise.Dane Turner and Douglas Drak contributed equally to this workSydney Medical School, University of Sydney, Sydney, NSW, AustraliaCentral Clinical School, University of Sydney, Sydney, NSW, AustraliaDane Turner, Catherine C. O’Connor, David J. Templeton & David M. GraceyRPA Sexual Health, Sydney Local Health District, Sydney, NSW, AustraliaKirby Institute, UNSW Sydney, Sydney, NSW, AustraliaRenal Unit, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, AustraliaYou can also search for this author in
This included a waiver of consent, permitting access to identified health data.A retrospective review was conducted of HIV-positive patients who attend an inner-city publicly funded sexual health service in Sydney, Australia for routine HIV care.

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